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These effects are accompanied by reduced c-kit CD expression, a marker associated with leukemia stem cells LSCs. It blocks hematologic tumors in vivo and reduces MLL leukemia tumor burden. Media is changed at day 4, viable cell numbers are restored to the original concentration and compounds are re-supplied.
Chemical formula is case sensitive. Choose Selective Histone Methyltransferase Inhibitors. Serial Dilutions Concertration start: MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice.
BCR503 Datasheet, Equivalent, Cross Reference Search
Not for human use. Prolonged treatment 38 days with MI induces no toxicity in mice as reflected by no alterations in the body weight and no morphological changes in liver and kidney tissues. The Selleck molarity calculator is based on the following equation: Calculate the dilution required to prepare a stock solution.
We do not sell to patients. MI is also very effective in inducing differentiation of MLL leukemia cells and substantially increases expression of CD11b, a myeloid differentiation marker. The cell growth inhibitory effect of MI is time-dependent, with a pronounced effect achieved after days of treatment. The Selleck dilution calculator is based on the following equation: In vivo MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice.
Bio Calculators Molarity Calculator Molarity Calculator Calculate the mass, volume or concentration required for a solution. Histone Methyltransferase Signaling Pathway Map.
The Selleck dilution calculator is based on the following equation:. Answers to questions you may have can be found in the inhibitor handling instructions. Treatment with sub-micromolar concentrations of MI also leads to markedly reduced expression of Hoxa9 and Meis1, downstream targets of MLL fusion proteins substantially upregulated in MLL leukemias . Dilution Calculator Dilution Calculator Calculate the dilution required to prepare a stock solution.
Calculate the mass, volume or concentration required for a solution.
To calculate molar mass of a chemical compound, please enter its chemical formula and click ‘Calculate’. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines GI50 at nM nM rangebut only a minimal effect in human leukemia cell lines without MLL translocations.
BCR Datasheet(PDF) – Siemens Semiconductor Group
Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments. Menin-MLL interaction  Cell-free assay. MI could substantially improve survival of MLL leukemic mice and does not impair normal hematopoiesis in vivo . For viability assays, leukemia cells are plated at relevant concentrations and datashest with compounds or 0.
For cell differentiation studies, leukemia cells are treated with menin-MLL inhibitors for 5003 days, then harvested, washed and incubated with Pacific Blue rat anti-mouse CD11b antibody before being analyzed by flow cytometry.
References  Borkin D, et al.
BCR Datasheet, PDF – Qdatasheet
Molecular mass molecular weight is the mass of one molecule of a substance and is expressed in the unified atomic mass units u. Tech Support Answers to questions you may have can be found in the inhibitor handling instructions. Bbcr equation is commonly abbreviated as: Products are for research use only.
The Selleck molarity calculator is based on the following equation:. This is normal and is due to slight batch-to-batch variations. Molecular Weight Calculator Molecular Weight Calculator Enter the chemical formula of a compound to calculate its molar mass and elemental composition: