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HLA alleles determine differences in human natural killer cell responsiveness and potency. Linkage disequilibrium organization of the human KIR superlocus: Amounts shown in italicized text are for items listed in currency other than Canadian dollars and are approximate conversions to Canadian dollars based upon Bloomberg’s conversion rates.


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Immunology 2: Genetic control of human NK cell repertoire. The Supplementary Material for this article can be found online at http: Best Match Best Match. The role of KIR genes and ligands in leukemia surveillance.

Until recently, legrans standard methods are used to type KIR genes at allelic level. Tissue Antigens 72 4: Previous price EUR In parallel, raw KIR sequences were aligned and visualized using the Profiler software version 1. In this step, calculation for depth of each position and the number of sequences used for each allele are determined. Curr Opin Immunol 24 2: Investigation of killer cell immunoglobulinlike receptor gene diversity: J Immunol Tissue Antigens 72 1: It may be a cheaper method than exome capture Quality control procedure for the library preparation included verification of fragment size before and after purification by using the QiAxcel Advanced System QiAgen, Courtaboeuf, France.


Tissue Antigens 72 6: The first three steps are managed in a Linux environment.

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Immunogenetics 62 11— Each allele is scored for quality control as per the European Federation for Immunogenetics guideline. Number of bids and legranc amounts may be slightly out of date.

Extensive variation in gene copy number at the killer immunoglobulin-like receptor locus in humans. Results are presented according to the centromeric or telomeric localization of KIR genes on human genome.

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You’ll receive email and Feed alerts when new items arrive. Front Immunol 4: Published online May Other Circuit Breakers J Immunol 3: Hum Mol Genet 19 5: Due to the time-consuming nature of manual KIR allele assignment, lehrand different algorithms are needed to ensure the reliability of NGS-based typing methods for the identification of KIR allele polymorphisms.

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Combined genotypic and phenotypic killer cell Ig-like receptor analyses reveal KIR2DL3 alleles displaying unexpected monoclonal antibody reactivity: The authors are most grateful to Audrey Donnart, Dr. Assignment of all sequences is done using a database, highlighting all mismatches compared 0415 reference and also differences between KIR alleles selected.

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However, substantial risks of morbidity and mortality caused by disease relapse 2graft-vs-host-disease GvHD 3and infection 4 are still prevalent after related, or unrelated HSCT. Format see all Format. The implementation of our suitable NGS.

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Discrepancies are shown in italics for each KIR locus concerned. Brand see all Brand. Format see all Format. Relapse after allogeneic stem cell transplantation. Turn off email legeand. Nat Genet 39 9: In this step, the depth for each position and the number of sequences for each allele were calculated. Immunology 3: