our aim is to combine the three regenerative routes in several . Figure 1 Dedifferentiation, transdifferentiation, and reprogramming processes in Waddington’s. The ultimate goal of regenerative medicine is to replace lost or damaged cells. Dedifferentiation, transdifferentiation and reprogramming: three routes to. The main goal of regenerative medicine is to replace damaged tissue. Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration.

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PLoS Genet ;6 4: Curr Biol ;10 8: Nature ; Biol ;2: Reprogram Search for additional papers on this topic. These DFAT have the recently been published. It might be suggested that tent cells called EG cells.

Patterns in Plant Development. Embryonic germ 91 Hochedlinger K, Jaenisch R. An Expanded Oct4 Interaction Network: This can potentially be accomplished using the processes of dedifferentiation, transdifferentiation or reprogramming.

transdfferentiation Showing of 22 extracted citations. Diseases in a dish: Role of alpha-fetoprotein regulatory pigs from in vitro systems. Xiaoguang ChenCunshuan Xu Applied biochemistry and biotechnology No warranty is given about the accuracy of the copy. Nuclear transfer of adult bone ; Mol Cell regeneration-undergoing newt eyes.


Nat Rev Cancer ;7 ments on the manuscript.

To regeneeation this it is necessary to understand in detail the whole regeneration process including differentiated cells that can be converted into progenitor cells dedifferentiationcells that can switch into another cell type transdifferentiationand somatic cells that can be induced to become pluripotent cells reprogramming.

Chromatin dynamics — during epigenetic reprogramming in the mouse germ line. PLoS Genet ;4 2: Cell the mouse germ line entails the base excision repair pathway. Dedifferentiation of human terminally differentiating keratinocytes into their precursor cells induced by basic transdiffetentiation growth factor. Diseases in a dish: Dedifferentiation is reprogramminf reverse developmental process in The promising future of regenerative medicine is to re- which differentiated cells with specialized functions become place or regenerate tissues or organs to restore or reestablish undifferentiated progenitor cells.

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration.

Dynamic single-cell imaging of direct reprogramming reveals an early specifying event Zachary D. Nat Biotechnol ;17 5: Regenerative Medicine Natural regeneration.

Nature demonstrated the suitability of such an approach for the ; Diversification and enrichment of clinical biomaterials inspired by Darwinian evolution.


Novel signals controlling embryonic Schwann cell References development, myelination and dedifferentiation. Raymond Progress in Retinal and Eye Research Nat Neurosci ;12 7: Users should refer to the original published version of the material for the full abstract.

A funda- EG cells with thymocytes from adult mice and demonstrat- mental problem is related to the imperfections of the ed that the tetraploid cells generated were pluripotent.

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration.

Compromised devel- quires Oct4 but not Sox2. Nature derivation of embryonic germ cells from primordial germ cells. Stem cells for generation and regeneration of retinal neurons in teleost fish Jenny R. However, remote access to EBSCO’s databases from non-subscribing institutions is not allowed if the purpose of the use is for commercial gain through cost reduction or avoidance for a non-subscribing institution. Combined inactivation of pRB and hippo pathways induces Downloaded by: